Langley City firefighters, BC Ambulance paramedics and RCMP were on scene shortly after noon at 200th Street and 45A Avenue for a four-car pileup.
At least two cars and two mini-vans were involved in the crash, which included a head-on collision and possibly a sideswipe, said Cpl. Holly Marks, spokesperson for the Langley RCMP.
Marks said two people were taken to hospital, one by ground ambulance and one by Air Ambulance. The Air Ambulance patient suffered serious injuries but is expected to survive.
The cars and parts, including torn-off wheels, were scattered across four lanes.
Few details about the cause of the collision and the number of people injured were available immediately.
The RCMP had closed 200th Street in both directions from 44th Avenue in the south to at least 46th Avenue.
The police are asking anyone who witnessed the accident but has not spoken to investigators to please contact them at 604-532-3200.